Nolvadex is a type of product that is classified as Anti-Estrogens, a group of compounds that are known to reduce the overall levels of the estrogen activity in the body.
Nonetheless, although there are some anti-estrogens that do lower total estrogen levels floating in the body, not all anti-estrogens work this way, contrary to popular belief.
For example, Nolvadex is not lowering the amount of estrogen in the body at all.
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AIs vs SERMs
Anti Estrogens are made of Aromatase Inhibitors (AIs) and Selective Estrogen Receptor Modulators (SERMs). Whilst AIs do work this way in lowering estrogen levels (like Arimidex – Anastrozole, Aromasin – Exemestane, and Femara – Letrozole), SERMs are actually working by selectively binding to some estrogen receptors blocking their actions. It blocks receptor sites and prevents the hormone from binding.
Nolvadex is a SERM (exactly as Clomid – Clomiphene Citrate is) and has various different actions in various different parts of the body. For example, it blocks estrogen activity in breast tissues, but it boosts estrogen activity in the liver.
The main active ingredient in Nolvadex is Tamoxifen Citrate. The compound can be found sold as numerous other brand names. This is an orally active drug classified as a SERM (and therefore anti estrogen) and is the first line treatment for estrogen receptor positive breast cancer but is also one of the most popular products for Post Cycle Therapy (PCT).
Nolvadex used for medical purposes is prescribed by a doctor – so use the compound exactly as mentioned by the doctor. When Nolvadex is used for bodybuilding purposes, the tablets are used on a daily or every other day basis.
That’s because Nolvadex half life is long – very long. The half life is anywhere between 5 and 7 days, in rare cases, it is slightly shorter or longer.
Nolvadex half life of 6 days (as a reference point) means that the compound takes slowly to fully kick in your body and that’s why you still need to use it regularly on either every day or every other day basis.
- As in terms of Tamoxifen Citrate – Nolvadex dosage; that’s highly individual. It can go as little as 10 mg every other day to as high as 80 mg every day.
Remember that Tamoxifen (Nolvadex) doesn’t reduce the estrogen levels in the body. It only blocks the estrogen activity in specific parts of the body (and boosts them in others).
In the breast tissues – it blocks the estrogen receptors and that’s how it is helpful for gynecomastia and breast cancer. But in the liver, it shows estrogenic effects. That’s helpful for preventing liver damage that is likely to occur from the use of steroids.
Plus to that, Nolvadex might be helpful at offering a better HDL and LDL balance, helping get healthier cholesterol (which is known that steroids might have a negative effect too).
But best – Nolvadex (Tamoxifen) is used for Post Cycle Therapy (PCT) plans because it blocks estrogen reaching the pituitary gland. It doesn’t offer signals to the hypothalamus to stop releasing gonadotropins. This results in more gonadotropins (protein hormones) which therefore results in more LH and FSH. That’s how testosterone is synthesized because of the more LH – the more testosterone.
So, Tamoxifen Citrate is great for PCT plans as it boosts the natural production of testosterone.
Nolvadex in Bodybuilding
As mentioned, Nolvadex (Tamoxifen Citrate) is either used for gynecomastia treatment and prevention during the use of aromatized steroids or for PCT plans.
Because Nolvadex half life is 5-7 days, the compound is used on either a daily or every other day basis for it to build up in the system, regardless of what’s the purpose of running it.
- When used for gynecomastia, Tamoxifen is usually used between 20-80 mg per day for best results.
- For PCT plans, the dosages are slightly lower. It can be administered in a range between 10 and 40 mg per day, or even every other day, depending on how you feel on it.
The Nolvadex PCT plan usually lasts 4 weeks, but length can be adjusted, exactly as dosage.
Nolvadex Side Effects
Although it is recommended to use it on a daily basis (despite long Nolvadex half life of 5-7 days) to allow it to properly build up in your system, some people use it on every other day basis in order to avoid the side effects. That’s mainly when daily basis administration is too much.
Some Tamoxifen Citrate side effects that can be mentioned include:
- Muscle aches
- Mood changes
- Dry joints
- Decreased or increased libido
- And others as well
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